Isolation of Human Monoclonal Antibodies That Potently Neutralize Human Cytomegalovirus Infection by Targeting Different Epitopes on the gH/gL/UL128-131A Complex

Human cytomegalovirus (HCMV) is a widely circulating pathogen that causes severe disease in immunocompromised patients and infected fetuses. By immortalizing memory B cells from HCMV-immune donors, we isolated a panel of human monoclonal antibodies that neutralized at extremely low concentrations (9...

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Autors principals: Macagno, Annalisa, Bernasconi, Nadia L., Vanzetta, Fabrizia, Dander, Erica, Sarasini, Antonella, Revello, Maria Grazia, Gerna, Giuseppe, Sallusto, Federica, Lanzavecchia, Antonio
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798344/
https://ncbi.nlm.nih.gov/pubmed/19889756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01809-09
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