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Prostaglandin Promotion of Osteocyte Gap Junction Function through Transcriptional Regulation of Connexin 43 by Glycogen Synthase Kinase 3/β-Catenin Signaling

Gap junction intercellular communication in osteocytes plays an important role in bone remodeling in response to mechanical loading; however, the responsible molecular mechanisms remain largely unknown. Here, we show that phosphoinositide-3 kinase (PI3K)/Akt signaling activated by fluid flow shear s...

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Hlavní autoři: Xia, Xuechun, Batra, Nidhi, Shi, Qian, Bonewald, Lynda F., Sprague, Eugene, Jiang, Jean X.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798309/
https://ncbi.nlm.nih.gov/pubmed/19841066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01844-08
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