Retroviral transfer of a murine cDNA for multidrug resistance confers pleiotropic drug resistance to cells without prior drug selection.

We have constructed a retrovirus expression vector that carries the murine mdr cDNA transcribed under the control of the human H4 histone promoter to examine the feasibility of efficiently transferring a multidrug resistance phenotype to cells without requiring drug selection. This approach will fac...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Guild, B C, Mulligan, R C, Gros, P, Housman, D E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279820/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3422751/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.5.1595
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