DIRECTED EVOLUTION AND STRUCTURAL CHARACTERIZATION OF A SIMVASTATIN SYNTHASE

Enzymes from natural product biosynthetic pathways are attractive candidates for creating tailored biocatalysts to produce semisynthetic pharmaceutical compounds. LovD is an acyltransferase that converts the inactive monacolin J acid (MJA) into the cholesterol-lowering lovastatin. LovD can also synt...

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Autori principali: Gao, Xue, Xie, Xinkai, Pashkov, Inna, Sawaya, Michael R., Laidman, Janel, Zhang, Wenjun, Cacho, Ralph, Yeates, Todd O., Tang, Yi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798062/
https://ncbi.nlm.nih.gov/pubmed/19875080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.09.017
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