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Efficient Synthesis of Simvastatin by Use of Whole-Cell Biocatalysis
Simvastatin is a semisynthetic derivative of the fungal polyketide lovastatin and is an important drug for lowering cholesterol levels in adults. We have developed a one-step, whole-cell biocatalytic process for the synthesis of simvastatin from monacolin J. By using an Escherichia coli strain overe...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1855665/ https://ncbi.nlm.nih.gov/pubmed/17277201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02820-06 |
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