ATP-sensitive K+ channels that are blocked by hypoglycemia-inducing sulfonylureas in insulin-secreting cells are activated by galanin, a hyperglycemia-inducing hormone.

The action of the hyperglycemia-inducing hormone galanin, a 29-amino acid peptide named from its N-terminal glycine and C-terminal amidated alanine, was studied in rat insulinoma (RINm5F) cells using electrophysiological and 86Rb+ flux techniques. Galanin hyperpolarizes and reduces spontaneous elect...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	de Weille, J, Schmid-Antomarchi, H, Fosset, M, Lazdunski, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279757/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2448801/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.4.1312
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