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Structure of the hDmc1-ssDNA Filament Reveals the Principles of Its Architecture

In eukaryotes, meiotic recombination is a major source of genetic diversity, but its defects in humans lead to abnormalities such as Down's, Klinefelter's and other syndromes. Human Dmc1 (hDmc1), a RecA/Rad51 homologue, is a recombinase that plays a crucial role in faithful chromosome segr...

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Autori principali: Okorokov, Andrei L., Chaban, Yuriy L., Bugreev, Dmitry V., Hodgkinson, Julie, Mazin, Alexander V., Orlova, Elena V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797393/
https://ncbi.nlm.nih.gov/pubmed/20062530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008586
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