High Resolution NMR-based Model for the Structure of a scFv-IL-1β Complex: POTENTIAL FOR NMR AS A KEY TOOL IN THERAPEUTIC ANTIBODY DESIGN AND DEVELOPMENT

Monoclonal antibodies have recently started to deliver on their promise as highly specific and active drugs; however, a more effective, knowledge-based approach to the selection, design, and optimization of potential therapeutic antibodies is currently limited by the surprising lack of detailed stru...

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Autori principali: Wilkinson, Ian C., Hall, Catherine J., Veverka, Vaclav, Shi, Jiye Y., Muskett, Frederick W., Stephens, Paul E., Taylor, Richard J., Henry, Alistair J., Carr, Mark D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797264/
https://ncbi.nlm.nih.gov/pubmed/19776018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025304
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