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Identification of the GATA Factor TRPS1 as a Repressor of the Osteocalcin Promoter

A proteomic analysis of proteins bound to the osteocalcin OSE2 sequence of the mouse osteocalcin promoter identified TRPS1 as a regulator of osteocalcin transcription. Mutations in the TRPS1 gene are responsible for human tricho-rhino-phalangeal syndrome, which is characterized by skeletal and crani...

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Autors principals: Piscopo, Denise M., Johansen, Eric B., Derynck, Rik
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797240/
https://ncbi.nlm.nih.gov/pubmed/19759027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.052316
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