Mitochondrial Localization of PARP-1 Requires Interaction with Mitofilin and Is Involved in the Maintenance of Mitochondrial DNA Integrity

Poly(ADP-ribose)polymerase-1 (PARP-1) is a predominantly nuclear enzyme that exerts numerous functions in cellular physiology and pathology, from maintenance of DNA stability to transcriptional regulation. Through a proteomic analysis of PARP-1 co-immunoprecipitation complexes, we identified Mitofil...

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Detalhes bibliográficos
Main Authors: Rossi, Marianna N., Carbone, Mariarosaria, Mostocotto, Cassandra, Mancone, Carmine, Tripodi, Marco, Maione, Rossella, Amati, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797232/
https://ncbi.nlm.nih.gov/pubmed/19762472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025882
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