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Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells
APPL1 is a newly identified adiponectin receptor-binding protein that positively mediates adiponectin signaling in cells. Here we report that APPL2, an isoform of APPL1 that forms a dimer with APPL1, can interacts with both AdipoR1 and AdipoR2 and acts as a negative regulator of adiponectin signalin...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2797231/ https://ncbi.nlm.nih.gov/pubmed/19661063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.010355 |
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