Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells

APPL1 is a newly identified adiponectin receptor-binding protein that positively mediates adiponectin signaling in cells. Here we report that APPL2, an isoform of APPL1 that forms a dimer with APPL1, can interacts with both AdipoR1 and AdipoR2 and acts as a negative regulator of adiponectin signalin...

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Detalhes bibliográficos
Main Authors: Wang, Changhua, Xin, Xiaoban, Xiang, Ruihua, Ramos, Fresnida J., Liu, Meilian, Lee, Hak Joo, Chen, Hongzhi, Mao, Xuming, Kikani, Chintan K., Liu, Feng, Dong, Lily Q.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797231/
https://ncbi.nlm.nih.gov/pubmed/19661063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.010355
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