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Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model
Humans who carry a point mutation in the gene coding for alcohol dehydrogenase-1B (ADH1B*2; Arg47His) are markedly protected against alcoholism. Although this mutation results in a 100-fold increase in enzyme activity, it has not been reported to cause higher levels of acetaldehyde, a metabolite of...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Federation of American Societies for Experimental Biology
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2797030/ https://ncbi.nlm.nih.gov/pubmed/19710201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-132563 |
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