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Evidence for a role of vertebrate Disp1 in long-range Shh signaling

Dispatched 1 (Disp1) encodes a twelve transmembrane domain protein that is required for long-range sonic hedgehog (Shh) signaling. Inhibition of Disp1 function, both by RNAi or dominant-negative constructs, prevents secretion and results in the accumulation of Shh in source cells. Measuring the Shh...

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Detalles Bibliográficos
Main Authors: Etheridge, L. Alton, Crawford, T. Quinn, Zhang, Shile, Roelink, Henk
Formato: Artigo
Idioma:Inglês
Publicado: Company of Biologists 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796928/
https://ncbi.nlm.nih.gov/pubmed/20023168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.043547
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