Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature

There is a need for novel strategies that target tumor vasculature, specifically those that synergize with cytotoxic therapy, in order to overcome resistance that can develop with current therapeutics. A chemistry-driven drug discovery screen was employed to identify novel compounds that inhibit end...

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Autori principali: Geng, Ling, Rachakonda, Girish, Morré, D. James, Morré, Dorothy M., Crooks, Peter A., Sonar, Vijayakumar N., Roti, Joseph L. Roti, Rogers, Buck E., Greco, Suellen, Ye, Fei, Salleng, Kenneth J., Sasi, Soumya, Freeman, Michael L., Sekhar, Konjeti R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Federation of American Societies for Experimental Biology 2009
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796904/
https://ncbi.nlm.nih.gov/pubmed/19395476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-130005
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