CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy

Previous studies have implicated CXCL12 in the neuropathogenesis of HIV infection. Proteolysis of CXCL12 generates a neurotoxic molecule, CXCL12(5-67), which engages and activates CXCR3, in addition to exhibiting increased expression in the brains of patients with HIV-associated dementia (HAD). Here...

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Detalhes bibliográficos
Main Authors: Zhu, Yu, Vergote, David, Pardo, Carlos, Noorbakhsh, Farshid, McArthur, Justin C., Hollenberg, Morley D., Overall, Christopher M., Power, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2009
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796902/
https://ncbi.nlm.nih.gov/pubmed/19380511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-128819
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