Heightened Endoplasmic Reticulum Stress in the Lungs of Patients with Chronic Obstructive Pulmonary Disease: The Role of Nrf2-Regulated Proteasomal Activity

Rationale: Nuclear factor erythroid 2–related factor 2 (Nrf2), an important regulator of lung antioxidant defenses, declines in chronic obstructive pulmonary disease (COPD). However, Nrf2 also regulates the proteasome system that degrades damaged and misfolded proteins. Because accumulation of misfo...

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Detalhes bibliográficos
Main Authors: Malhotra, Deepti, Thimmulappa, Rajesh, Vij, Neeraj, Navas-Acien, Ana, Sussan, Thomas, Merali, Salim, Zhang, Li, Kelsen, Steven G., Myers, Allen, Wise, Robert, Tuder, Rubin, Biswal, Shyam
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2009
Assuntos:
B. Chronic Obstructive Pulmonary Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796732/
https://ncbi.nlm.nih.gov/pubmed/19797762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200903-0324OC
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