Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1

Rationale: Oxidative stress is a key contributor in chronic obstructive pulmonary disease (COPD) pathogenesis caused by cigarette smoking. NRF2, a redox-sensitive transcription factor, dissociates from its inhibitor, KEAP1, to induce antioxidant expression that inhibits oxidative stress. Objectives:...

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Autori principali: Malhotra, Deepti, Thimmulappa, Rajesh, Navas-Acien, Ana, Sandford, Andrew, Elliott, Mark, Singh, Anju, Chen, Linan, Zhuang, Xiaoxi, Hogg, James, Pare, Peter, Tuder, Rubin M., Biswal, Shyam
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2008
Soggetti:
B. Chronic Obstructive Pulmonary Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542433/
https://ncbi.nlm.nih.gov/pubmed/18556627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200803-380OC
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