Direct Inhibition of Hypoxia-Inducible Transcription Factor Complex with Designed Dimeric Epidithiodiketopiperazine

Selective blockade of hypoxia-inducible gene expression by designed small molecules would prove valuable in suppressing tumor angiogenesis, metastasis and altered energy metabolism. We report the design, synthesis, and biological evaluation of dimeric epidithiodiketopiperazine (ETP) small molecule t...

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Detalhes bibliográficos
Main Authors: Block, Katherine M., Wang, Hui, Szabo, Lajos Z., Polaske, Nathan W., Henchey, Laura K., Dubey, Ramin, Kushal, Swati, Laszlo, Csaba F., Makhoul, Joshua, Song, Zuohe, Meuillet, Emmanuelle J., Olenyuk, Bogdan Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796602/
https://ncbi.nlm.nih.gov/pubmed/20000859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja807601b
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