Targeting the Epidermal Growth Factor Receptor in Epithelial Ovarian Cancer: Current Knowledge and Future Challenges

The epidermal growth factor receptor is overexpressed in up to 60% of ovarian epithelial malignancies. EGFR regulates complex cellular events due to the large number of ligands, dimerization partners, and diverse signaling pathways engaged. In ovarian cancer, EGFR activation is associated with incre...

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Detalhes bibliográficos
Main Authors: Siwak, Doris R., Carey, Mark, Hennessy, Bryan T., Nguyen, Catherine T., McGahren Murray, Mollianne J., Nolden, Laura, Mills, Gordon B.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2010
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796463/
https://ncbi.nlm.nih.gov/pubmed/20037743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/568938
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