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Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis

OBJECTIVE: Deletion of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. VSMC are an important component of atherosclerotic plaques, responsible for promoting plaque stability in advanced lesions. Fibrous caps of unstable plaques contain less collagen and ECM components and...

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Main Authors: Fernández-Hernando, Carlos, József, Levente, Jenkins, Deborah, Lorenzo, Annarita Di, Sessa, William C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796372/
https://ncbi.nlm.nih.gov/pubmed/19762778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.109.196394
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