Combined Therapy of Dietary Fish Oil and Stearoyl-CoA Desaturase 1 (SCD1) Inhibition Prevents The Metabolic Syndrome and Atherosclerosis

BACKGROUND: Stearoyl-CoA desaturase 1 (SCD1) is a critical regulator of energy metabolism and inflammation. We have previously reported that inhibition of SCD1 in hyperlipidemic mice fed a saturated fatty acid (SFA)-enriched diet prevented development of the metabolic syndrome, yet surprisingly prom...

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Hlavní autoři: Brown, J. Mark, Chung, Soonkyu, Sawyer, Janet K., Degirolamo, Chiara, Alger, Heather M., Nguyen, Tam M., Zhu, Xuewei, Duong, My-Ngan, Brown, Amanda L., Lord, Caleb, Shah, Ramesh, Davis, Matthew A., Kelley, Kathryn, Wilson, Martha D., Madenspacher, Jennifer, Fessler, Michael B., Parks, John S., Rudel, Lawrence L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796293/
https://ncbi.nlm.nih.gov/pubmed/19834103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.109.198036
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