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Combining Structure and Sequence Information Allows Automated Prediction of Substrate Specificities within Enzyme Families

An important aspect of the functional annotation of enzymes is not only the type of reaction catalysed by an enzyme, but also the substrate specificity, which can vary widely within the same family. In many cases, prediction of family membership and even substrate specificity is possible from enzyme...

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Main Authors: Röttig, Marc, Rausch, Christian, Kohlbacher, Oliver
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796266/
https://ncbi.nlm.nih.gov/pubmed/20072606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000636
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