In vitro transcription of eukaryotic genes is affected differently by the degree of DNA supercoiling.

In a posterior silk gland extract, covalently closed circular (ccc) DNA is in a superhelical state that supports more transcription of fibroin gene than does linear DNA. A HeLa cell extract showed neither the supercoiling activity nor the preference for the transcription of ccc DNA over linear DNA....

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Hirose, S, Suzuki, Y
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1988
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279626/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2829200/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.3.718
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