HDAC6 Regulates Androgen Receptor Hypersensitivity and Nuclear Localization via Modulating Hsp90 Acetylation in Castration-Resistant Prostate Cancer

The development of castration-resistant prostate cancer (PCa) requires that under castration conditions, the androgen receptor (AR) remains active and thus nuclear. Heat shock protein 90 (Hsp90) plays a key role in androgen-induced and -independent nuclear localization and activation of AR. Histone...

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Autores principales: Ai, Junkui, Wang, Yujuan, Dar, Javid A., Liu, June, Liu, Lingqi, Nelson, Joel B., Wang, Zhou
Formato: Artigo
Lenguaje:Inglês
Publicado: The Endocrine Society 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796151/
https://ncbi.nlm.nih.gov/pubmed/19855091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0188
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