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Growth Hormone-Activated STAT5 May Indirectly Stimulate IGF-I Gene Transcription through HNF-3γ

IGF-I is abundantly expressed in the liver under the stimulation of GH. We showed previously that expression of hepatocyte nuclear factor (HNF)-3γ, a liver-enriched transcription factor, was strongly stimulated by GH in bovine liver. In this study, we determined whether GH-increased HNF-3γ might con...

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Detalhes bibliográficos
Main Authors: Eleswarapu, Satyanarayana, Ge, Xiaomei, Wang, Ying, Yu, Jie, Jiang, Honglin
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796150/
https://ncbi.nlm.nih.gov/pubmed/19819986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0178
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