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Modifiers of von Willebrand factor identified by natural variation in inbred strains of mice

Type 1 von Willebrand disease (VWD) is the most common inherited human bleeding disorder. However, diagnosis is complicated by incomplete penetrance and variable expressivity, as well as wide variation in von Willebrand factor (VWF) levels among the normal population. Previous work has exploited the...

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Autores principales: Shavit, Jordan A., Manichaikul, Ani, Lemmerhirt, Heidi L., Broman, Karl W., Ginsburg, David
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796139/
https://ncbi.nlm.nih.gov/pubmed/19789385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-233213
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