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Activating Mutations in TOR Are in Similar Structures As Oncogenic Mutations in PI3KCα
[Image: see text] TOR (Target of Rapamycin) is a highly conserved Ser/Thr kinase and a central controller of cell growth. Using the crystal structure of the related lipid kinase PI3KCγ, we built a model of the catalytic region of TOR, from the FAT domain to near the end of the FATC domain. The model...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical Society
2009
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2796128/ https://ncbi.nlm.nih.gov/pubmed/19902965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb900193e |
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