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In situ hybridization histochemistry and immunocytochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model of peripheral inflammation and hyperalgesia.

Dynorphin, an opioid peptide, is thought to play an important role in the modulation of nociceptive neural circuits at the level of the spinal cord. In a model of peripheral inflammation and hyperalgesia, an oligodeoxyribonucleotide probe complementary to a portion of preprodynorphin mRNA and antise...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ruda, M A, Iadarola, M J, Cohen, L V, Young, W S
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1988
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC279603/
https://ncbi.nlm.nih.gov/pubmed/2893375
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