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Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice.

We find a strong synergism between tumor necrosis factor (TNF) and bacteria or their products. Endotoxin-"free" recombinant TNF, even at very high doses (160 micrograms), did not alone cause hemorrhagic necrosis (HN) in the skin of normal mice. Similarly, TNF alone had a low systemic toxicity in tum...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Rothstein, J L, Schreiber, H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279600/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3422444/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.2.607
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