Detecting single-nucleotide polymorphism by single-nucleotide polymorphism interactions in rheumatoid arthritis using a two-step approach with machine learning and a Bayesian threshold least absolute shrinkage and selection operator (LASSO) model

The objective of this study was to detect interactions between relevant single-nucleotide polymorphisms (SNPs) associated with rheumatoid arthritis (RA). Data from Problem 1 of the Genetic Analysis Workshop 16 were used. These data consisted of 868 cases and 1,194 controls genotyped with the 500 k I...

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Hauptverfasser: González-Recio, Oscar, de Maturana, Evangelina López, Vega, Andrés T, Engelman, Corinne D, Broman, Karl W
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2009
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Proceedings
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795964/
https://ncbi.nlm.nih.gov/pubmed/20018057
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