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Combining least absolute shrinkage and selection operator (LASSO) and principal-components analysis for detection of gene-gene interactions in genome-wide association studies
Variable selection in genome-wide association studies can be a daunting task and statistically challenging because there are more variables than subjects. We propose an approach that uses principal-component analysis (PCA) and least absolute shrinkage and selection operator (LASSO) to identify gene-...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
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BioMed Central
2009
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2795963/ https://ncbi.nlm.nih.gov/pubmed/20018056 |
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