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The effect of minor allele frequency on the likelihood of obtaining false positives

Determining the most promising single-nucleotide polymorphisms (SNPs) presents a challenge in genome-wide association studies, when hundreds of thousands of association tests are conducted. The power to detect genetic effects is dependent on minor allele frequency (MAF), and genome-wide association...

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Autors principals: Tabangin, Meredith E, Woo, Jessica G, Martin, Lisa J
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795940/
https://ncbi.nlm.nih.gov/pubmed/20018033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1753-6561-3-S7-S41
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