Assessing the impact of global versus local ancestry in association studies

BACKGROUND: To account for population stratification in association studies, principal-components analysis is often performed on single-nucleotide polymorphisms (SNPs) across the genome. Here, we use Framingham Heart Study (FHS) Genetic Analysis Workshop 16 data to compare the performance of local a...

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Main Authors: Kang, Sun Jung, Larkin, Emma K, Song, Yeunjoo, Barnholtz-Sloan, Jill, Baechle, Dan, Feng, Tao, Zhu, Xiaofeng
格式: Artigo
語言:Inglês
出版: BioMed Central 2009
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Proceedings
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795878/
https://ncbi.nlm.nih.gov/pubmed/20017971
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