The nuclear receptor RORα exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes

Astrocytes and one of their products, IL-6, not only support neurons but also mediate inflammation in the brain. Retinoid-related orphan receptor-α (RORα) transcription factor has related roles, being neuro-protective and, in peripheral tissues, anti-inflammatory. We examined the relation of RORα to...

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Detalhes bibliográficos
Main Authors: Journiac, Nathalie, Jolly, Sarah, Jarvis, Christopher, Gautheron, Vanessa, Rogard, Monique, Trembleau, Alain, Blondeau, Jean-Paul, Mariani, Jean, Vernet-der Garabedian, Béatrice
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795519/
https://ncbi.nlm.nih.gov/pubmed/19955433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911782106
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