SCAP is required for timely and proper myelin membrane synthesis

Myelination requires a massive increase in glial cell membrane synthesis. Here, we demonstrate that the acute phase of myelin lipid synthesis is regulated by sterol regulatory element-binding protein (SREBP) cleavage activation protein (SCAP), an activator of SREBPs. Deletion of SCAP in Schwann cell...

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Detalhes bibliográficos
Main Authors: Verheijen, Mark H. G., Camargo, Nutabi, Verdier, Valerie, Nadra, Karim, de Preux Charles, Anne-Sophie, Médard, Jean-Jacques, Luoma, Adrienne, Crowther, Michelle, Inouye, Hideyo, Shimano, Hitoshi, Chen, Su, Brouwers, Jos F., Helms, J. Bernd, Feltri, M. Laura, Wrabetz, Lawrence, Kirschner, Daniel, Chrast, Roman, Smit, August. B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795508/
https://ncbi.nlm.nih.gov/pubmed/19948958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905633106
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