Proposed mechanism for stability of proteins to evolutionary mutations
It is shown that the sequence-ordering tendencies induced by design into different fast-folding, thermally stable native structures interfere. This interference results in a type of quasiorthogonality between optimal native structures, which divides sequence space into fast-folding, thermally stable...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27955/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9724764/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.18.10682 |
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