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Reaction mechanisms of thiamin diphosphate enzymes: defining states of ionization and tautomerization of the cofactor at individual steps

We summarize the currently available information regarding the state of ionization and tautomerization of the 4′-aminopyrimidine ring of the thiamine diphosphate on enzymes requiring this coenzyme. This coenzyme forms a series of covalent intermediates with its substrates as an electrophilic catalys...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Nemeria, Natalia S., Chakraborty, Sumit, Balakrishnan, Anand, Jordan, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795322/
https://ncbi.nlm.nih.gov/pubmed/19476485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.06964.x
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