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Reaction mechanisms of thiamin diphosphate enzymes: defining states of ionization and tautomerization of the cofactor at individual steps
We summarize the currently available information regarding the state of ionization and tautomerization of the 4′-aminopyrimidine ring of the thiamine diphosphate on enzymes requiring this coenzyme. This coenzyme forms a series of covalent intermediates with its substrates as an electrophilic catalys...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2795322/ https://ncbi.nlm.nih.gov/pubmed/19476485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.06964.x |
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