Involvement of PKCα and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of µ-opioid receptors in mature brain neurons

BACKGROUND AND PURPOSE: The ability of an agonist to induce desensitization of the µ-opioid receptor (MOR) depends upon the agonist used. Furthermore, previous data suggest that the intracellular mechanisms underlying desensitization may be agonist-specific. We investigated the mechanisms underlying...

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Hlavní autoři: Bailey, CP, Oldfield, S, Llorente, J, Caunt, CJ, Teschemacher, AG, Roberts, L, McArdle, CA, Smith, FL, Dewey, WL, Kelly, E, Henderson, G
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2009
Témata:
Research Papers with Commentaries
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795264/
https://ncbi.nlm.nih.gov/pubmed/19309357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00140.x
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