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Distinct roles for Mitogen Activated Protein Kinase Phosphatase-1 (MKP-1) and ERK-MAPK in PTH1R signaling during osteoblast proliferation and differentiation

Parathyroid hormone (PTH) and PTH-related protein (PTHrP) activate one single receptor (PTH1R) which mediates catabolic and anabolic actions in bone. Activation of PTH1R modulates multiple intracellular signaling responses. We previously reported that PTH and PTHrP downregulate pERK1/2 and cyclin D1...

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Detalhes bibliográficos
Main Authors: Datta, Nabanita S., Kolailat, Rola, Fite, Alemu, Pettway, Glenda, Abou-Samra, Abdul B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795117/
https://ncbi.nlm.nih.gov/pubmed/19892016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2009.10.017
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