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Cardioprotective Activity of A Novel and Potent Competitive Inhibitor of Lactate Dehydrogenase

Alkaline incubation of NADH results in the formation of a very potent inhibitor of lactate dehydrogenase. High resolution mass spectroscopy along with NMR characterization clearly showed that the inhibitor is derived from attachment of a glycolic acid moiety to the 4-position of the dihydronicotinam...

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Detalhes bibliográficos
Main Authors: Kotlyar, Alexander B., Randazzo, Antonio, Honbo, Norman, Jin, Zhu-Qui, Karliner, Joel S., Cecchini, Gary
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794998/
https://ncbi.nlm.nih.gov/pubmed/19913538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2009.11.022
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