Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site

Albaflavenone synthase (CYP170A1) is a monooxygenase catalyzing the final two steps in the biosynthesis of this antibiotic in the soil bacterium, Streptomyces coelicolor A3(2). Interestingly, CYP170A1 shows no stereo selection forming equal amounts of two albaflavenol epimers, each of which is oxidi...

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Bibliographic Details
Main Authors: Zhao, Bin, Lei, Li, Vassylyev, Dmitry G., Lin, Xin, Cane, David E., Kelly, Steven L., Yuan, Hang, Lamb, David C., Waterman, Michael R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794785/
https://ncbi.nlm.nih.gov/pubmed/19858213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064683
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