Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site

Albaflavenone synthase (CYP170A1) is a monooxygenase catalyzing the final two steps in the biosynthesis of this antibiotic in the soil bacterium, Streptomyces coelicolor A3(2). Interestingly, CYP170A1 shows no stereo selection forming equal amounts of two albaflavenol epimers, each of which is oxidi...

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Bibliographische Detailangaben
Hauptverfasser: Zhao, Bin, Lei, Li, Vassylyev, Dmitry G., Lin, Xin, Cane, David E., Kelly, Steven L., Yuan, Hang, Lamb, David C., Waterman, Michael R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Enzyme Catalysis and Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794785/
https://ncbi.nlm.nih.gov/pubmed/19858213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064683
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