β Integrin Tyrosine Phosphorylation Is a Conserved Mechanism for Regulating Talin-induced Integrin Activation

Integrins are large membrane-spanning receptors fundamental to cell adhesion and migration. Integrin adhesiveness for the extracellular matrix is activated by the cytoskeletal protein talin via direct binding of its phosphotyrosine-binding-like F3 domain to the cytoplasmic tail of the β integrin sub...

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Detalhes bibliográficos
Main Authors: Anthis, Nicholas J., Haling, Jacob R., Oxley, Camilla L., Memo, Massimiliano, Wegener, Kate L., Lim, Chinten J., Ginsberg, Mark H., Campbell, Iain D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794784/
https://ncbi.nlm.nih.gov/pubmed/19843520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.061275
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