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Lack of Oxygen Deactivates Mitochondrial Complex I: IMPLICATIONS FOR ISCHEMIC INJURY?

For S-nitrosothiols and peroxynitrite to interfere with the activity of mitochondrial complex I, prior transition of the enzyme from its active (A) to its deactive, dormant (D) state is necessary. We now demonstrate accumulation of the D-form of complex I in human epithelial kidney cells after prolo...

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Detalhes bibliográficos
Main Authors: Galkin, Alexander, Abramov, Andrey Y., Frakich, Nanci, Duchen, Michel R., Moncada, Salvador
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794721/
https://ncbi.nlm.nih.gov/pubmed/19861410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.054346
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