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Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH(3)B(6) cells

Microdomains have been proposed to explain specificity in the myriad of possible cellular targets of cAMP. Local differences in cAMP levels can be generated by phosphodiesterases, which control the diffusion of cAMP. Here, we address the possibility that adenylyl cyclases, the source of cAMP, can be...

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Detalhes bibliográficos
Main Authors: Wachten, Sebastian, Masada, Nanako, Ayling, Laura-Jo, Ciruela, Antonio, Nikolaev, Viacheslav O., Lohse, Martin J., Cooper, Dermot M. F.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794711/
https://ncbi.nlm.nih.gov/pubmed/20016070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.058594
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