Alternative transcription and splicing of the human porphobilinogen deaminase gene result either in tissue-specific or in housekeeping expression.

Porphobilinogen deaminase [PBGD; porphobilinogen ammonia-lyase (polymerizing), EC 4.3.1.8] is a cytosolic enzyme involved in the heme biosynthetic pathway. Two isoforms of PBGD, encoded by two mRNAs differing solely in their 5' end, are known: one is found in all cells and the other is present only...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Chretien, S, Dubart, A, Beaupain, D, Raich, N, Grandchamp, B, Rosa, J, Goossens, M, Romeo, P H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279470/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3422427/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.1.6
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