Alternative transcription and splicing of the human porphobilinogen deaminase gene result either in tissue-specific or in housekeeping expression.

Porphobilinogen deaminase [PBGD; porphobilinogen ammonia-lyase (polymerizing), EC 4.3.1.8] is a cytosolic enzyme involved in the heme biosynthetic pathway. Two isoforms of PBGD, encoded by two mRNAs differing solely in their 5' end, are known: one is found in all cells and the other is present...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Chretien, S, Dubart, A, Beaupain, D, Raich, N, Grandchamp, B, Rosa, J, Goossens, M, Romeo, P H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279470/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3422427/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.1.6
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