Albumin-Binding and Tumor Vasculature Determine the Antitumor Effect of 15-Deoxy-Δ(12,14)-Prostaglandin-J(2) in vivo

15-Deoxy-Δ(12,14)-prostaglandin-J(2) (15d-PGJ(2)), a peroxisome proliferator-activated receptor γ (PPARγ) agonist, induces cell death in tumor cells in vitro; however, no study showed its in vivo effect on tumors. Here, we report that 15d-PGJ(2) shows antitumor effects in vivo in mice. However, its...

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Bibliographic Details
Main Authors: Prakash, Jai, Bansal, Ruchi, Post, Eduard, de Jager-Krikken, Alie, Lub-de Hooge, Marjolijn N, Poelstra, Klaas
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794516/
https://ncbi.nlm.nih.gov/pubmed/20019843
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