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A Stable Prefusion Intermediate of the Alphavirus Fusion Protein Reveals Critical Features of Class II Membrane Fusion
Alphaviruses infect cells via a low-pH-triggered membrane fusion reaction mediated by the class II virus fusion protein E1, an elongated molecule with three extramembrane domains (DI–III). E1 drives fusion by inserting its fusion peptide loop into the target membrane and refolding to a hairpin-like...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2794427/ https://ncbi.nlm.nih.gov/pubmed/19064260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.10.012 |
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