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A Stable Prefusion Intermediate of the Alphavirus Fusion Protein Reveals Critical Features of Class II Membrane Fusion
Alphaviruses infect cells via a low-pH-triggered membrane fusion reaction mediated by the class II virus fusion protein E1, an elongated molecule with three extramembrane domains (DI–III). E1 drives fusion by inserting its fusion peptide loop into the target membrane and refolding to a hairpin-like...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2794427/ https://ncbi.nlm.nih.gov/pubmed/19064260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.10.012 |
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