Requirement of Arsenic Biomethylation for Oxidative DNA Damage

BACKGROUND: Inorganic arsenic is an environmental carcinogen that may act through multiple mechanisms including formation of methylated derivatives in vivo. Sodium arsenite (up to 5.0 μM) renders arsenic methylation–competent TRL1215 rat liver epithelial cells tumorigenic in nude mice at 18 weeks of...

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Bibliographic Details
Main Authors: Kojima, Chikara, Ramirez, Dario C., Tokar, Erik J., Himeno, Seiichiro, Drobná, Zuzana, Stýblo, Miroslav, Mason, Ronald P., Waalkes, Michael P.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794302/
https://ncbi.nlm.nih.gov/pubmed/19933942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djp414
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